Ahmad M. AlAli BDS, MSc, Daniel Hawkins DMD, Sarah Glass DDS 

https://doi.org/10.1016/j.oooo.2023.09.005

Abstract

Peripheral ameloblastoma (PA) is a rare variant of ameloblastoma that presents as a slow-growing, painless mass in the gingival tissues or alveolar mucosa. It shares histological features with conventional ameloblastoma but is less invasive and aggressive. This case report describes a 51-year-old female with a PA that simultaneously or subsequently developed underlying squamous cell papilloma following mandibular third molar extraction. Clinical examination revealed a pedunculated gingival lesion mimicking squamous cell papilloma. Histopathological examination confirmed PA underlying squamous cell papilloma following excisional biopsy. Imaging revealed mild bone resorption, leading to a further soft tissue excision and minimal osteoectomy to rule out intraosseous involvement. The patient remained asymptomatic without signs of recurrence in the one-year follow-up. PA diagnosis can be challenging due to its clinical resemblance to other gingival lesions and histopathological features. Treatment typically involves surgical excision, with long-term follow-up recommended due to possible recurrence and malignant transformation.

Keywords

Peripheral ameloblastoma; squamous cell papilloma; gingival lesion